Speech Lab Publications
All publications on Pubmed
Matthew K. Leonard, Laura Gwilliams, Kristen K. Sellers, Jason E. Chung, Duo Xu, Gavin Mischler, Nima Mesgarani, Marleen Welkenhuysen, Barundeb Dutta, & Edward F. Chang (2023). Large-scale single-neuron speech sound encoding across the depth of human cortex. Nature.
https://doi.org/10.1038/s41586-023-06839-2
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Junfeng Lu, Yuanning Li, Zehao Zhao, Yanming Zhu, Ying Mao, Jinsong Wu, & Edward F. Chang (2023). Neural control of lexical tone production in human motor cortex. Nature Communications.
https://doi.org/10.1038/s41467-023-42175-9
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Yuanning Li, Gopala K. Anumanchipali, Abdelrahman Mohamed, Peili Chen, Laurel H. Carney, Junfeng Lu, Jinsong Wu, & Edward F. Chang (2023). Dissecting neural computations in the human auditory pathway using deep neural networks for speech. Nature Neuroscience.
https://doi.org/10.1038/s41593-023-01468-4
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Yulia Oganian, Ilina Bhaya-Grossman, Keith Johnson, & Edward F. Chang (2023). Vowel and formant representation in the human auditory speech cortex. Neuron.
https://doi.org/10.1016/j.neuron.2023.04.004
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Emily P. Stephen, Yuanning Li, Sean Metzger, Yulia Oganian, & Edward F. Chang (2023). Latent neural dynamics encode temporal context in speech. Hearing Research.
https://doi.org/10.1016/j.heares.2023.108838
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Sean L. Metzger, Kaylo T. Littlejohn, Alex B. Silva, David A. Moses, Margaret P. Seaton, Ran Wang, Maximilian E. Dougherty, Jessie R. Liu, Peter Wu, Michael A. Berger, Inga Zhuravleva, Adelyn Tu-Chan, Karunesh Ganguly, Gopala K. Anumanchipalli, & Edward F. Chang (2023). A high performance neuroprosthesis for speech decoding and avatar control. Nature.
https://doi.org/10.1038/s41586-023-06443-4
Deborah F. Levy, Alex B. Silva, Terri L. Scott, Jessie R. Liu, Sarah Harper, Lingyun Zhao, Patrick W. Hullett, Garret Kurteff, Stephen M. Wilson, Matthew K. Leonard, & Edward F. Chang (2023). Apraxia of speech with phonological alexia and agraphia following resection of the left middle precentral gyrus: illustrative case. Journal of Neurosurgery: Case Lessons.
https://doi.org/10.3171/CASE22504
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Alex B. Silva, Jessie R. Liu, Lingyun Zhao, Deborah F. Levy, Terri L. Scott, & Edward F. Chang (2022). A Neurosurgical Functional Dissection of the Middle Precentral Gyrus during Speech Production. Journal of Neuroscience.
https://doi.org/10.1523/jneurosci.1614-22.2022
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Sean L. Metzger, Jessie R. Liu, David A. Moses, Maximilian E. Dougherty, Margaret P. Seaton, Kaylo T. Littlejohn, Josh Chartier, Gopala K. Anumanchipalli, Adelyn Tu-Chan, Karunesh Ganguly, & Edward F. Chang (2022). Generalizable spelling using a speech neuroprosthesis in an individual with severe limb and vocal paralysis. Nature Communications.
https://doi.org/10.1038/s41467-022-33611-3
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Jason E. Chung, Kristin K. Sellers, Matthew K. Leonard, Laura Gwilliams, Duo Xu, Maximilian E. Dougherty, Viktor Kharazia, Sean L. Metzger, Marleen Welkenhuysen, Barundeb Dutta, & Edward F. Chang (2022). High-density single-unit human cortical recordings using the Neuropixels probe. Neuron.
https://doi.org/10.1016/j.neuron.2022.05.007
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Blake S. Wilson, Debara L. Tucci, David A. Moses, Edward F. Chang, Nancy M. Young, Fan-Gang Zeng, Nicholas A. Lesica, Andrés M. Bur, Hannah Kavookjian, Caroline Mussatto, Joseph Penn, Sara Goodwin, Shannon Kraft, Guanghui Wang, Jonathan M. Cohen, Geoffrey S. Ginsburg, Geraldine Dawson, & Howard H. Francis (2022). Harnessing the power of artificial intelligence in otolaryngology and the communication sciences. Journal of the Association for Research in Otolaryngology.
https://doi.org/10.1007/s10162-022-00846-2
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Maryam Bijanzadeh, Ankit N. Khambhati, Maansi Desai, Deanna L. Wallace, Alia Shafi, Heather E. Dawes, Virginia E. Sturm, & Edward F. Chang (2022). Decoding naturalistic affective behaviour from spectro-spatial features in multiday human iEEG. Nature Human Behavior.
https://doi.org/10.1038/s41562-022-01310-0
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Christina M. Merrick, Tanner C. Dixon, Assaf Breska, Jack Lin, Edward F. Chang, David King-Stephens, Kenneth D. Laxer, Peter B. Weber, Jose Carmena, Robert Thomas Knight, & Richard B. Ivry (2022). Left hemisphere dominance for bilateral kinematic encoding in the human brain. Elife.
https://doi.org/10.7554/eLife.69977
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Ashley Feinsinger, Nader Pouratian, Hamasa Ebadi, Ralph Adolphs, Richard Andersen, Michael S. Beauchamp, Edward F. Chang, Nathan E. Crone, Jennifer L. Collinger, Itzhak Fried, Adam Mamelak, Mark Richardson, Ueli Rutishauser, Sameer A. Sheth, Nanthia Suthana, Nitin Tandon, Daniel Yoshor, on behalf of the NIH Research Opportunities in Humans Consortium (2022). Ethical commitments, principles, and practices guiding intracranial neuroscientific research in humans. Neuron.
https://doi.org/10.1016/j.neuron.2021.11.011
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Nikhilesh Natraj, Daniel B. Silversmith, Edward F. Chang, & Karunesh Ganguly (2022). Compartmentalized dynamics within a common multi-area mesoscale manifold represent a repertoire of human hand movements. Neuron.
https://doi.org/10.1016/j.neuron.2021.10.002
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Alexander A. Aabedi, Benjamin Lipkin, Jasleen Kaur, Sofia Kakaizada, Claudia Valdivia, Sheantel Reihl, Jacob S. Young, Anthony T. Lee, Saritha Krishna, Mitchel S. Berger, Edward F. Chang, David Brang, & Shawn L. Hervey-Jumper (2021). Functional alterations in cortical processing of speech in glioma-infiltrated cortex. PNAS.
https://doi.org/10.1073/pnas.2108959118
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Ilina Bhaya-Grossman, & Edward F. Chang (2021). Speech Computations of the Human Superior Temporal Gyrus. Annual Review of Psychology.
https://doi.org/10.1146/annurev-psych-022321-035256
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Han G. Yi, Bharath Chandrasekaran, Kirill V. Nourski, Ariane E. Rhone, William L. Schuerman, Matthew A. Howard III, Edward F. Chang, & Matthew K. Leonard (2021). Learning nonnative speech sounds changes local encoding in the adult human cortex. PNAS.
https://doi.org/10.1073/pnas.2101777118
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Liberty S. Hamilton, Yulia Oganian, Jeffery Hall, & Edward F. Chang (2021). Parallel and distributed encoding of speech across human auditory cortex. Cell.
https://doi.org/10.1016/j.cell.2021.07.019
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David A. Moses*, Sean L. Metzger*, Jessie R. Liu*, Gopala K. Anumanchipalli, Joseph G. Makin, Pengfei F. Sun, Josh Chartier, Maximilian E. Dougherty, Patricia M. Liu, Gary M. Abrams, Adelyn Tu-Chan, Karunesh Ganguly, & Edward F. Chang (2021). Neuroprosthesis for Decoding Speech in a Paralyzed Person with Anarthria. New England Journal of Medicine.
(*Equally contributing authors.)
https://doi.org/10.1056/NEJMoa2027540
Yuanning Li, Claire Tang, Junfeng Lu, Jinsong Wu, & Edward F. Chang (2021). Human cortical encoding of pitch in tonal and non-tonal languages. Nature Communications.
https://doi.org/10.1038/s41467-021-21430-x
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Katsuaki Kojima, Yulia Oganian, Chang Cai, Anne Findlay, Edward F. Chang, & Srikantan Nagarajan (2020). Low-frequency neural tracking of speech envelope reflects evoked responses to acoustic edges. bioRxiv.
https://doi.org/10.1101/2020.04.02.022616
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Pengfei Sun, Gopala Anumanchipalli, & Edward F. Chang (2020). Brain2Char: a deep architecture for decoding text from brain recordings. Journal of Neural Engineering.
https://doi.org/10.1088/1741-2552/abc742
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Liberty S. Hamilton, Yulia Oganian, & Edward F. Chang (2020). Topography of speech-related acoustic and phonological feature encoding throughout the human core and parabelt auditory cortex. bioRxiv.
https://doi.org/10.1101/2020.06.08.121624
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Matthew K. Leonard, Ben Lucas, Shane Blau, David P. Corina, & Edward F. Chang (2020). Cortical Encoding of Manual Articulatory and Linguistic Features in American Sign Language. Current Biology.
https://doi.org/10.1016/j.cub.2020.08.048
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Neal P. Fox, Matthew K. Leonard, Matthias J. Sjerps, & Edward F. Chang (2020). Transformation of a temporal speech cue to a spatial neural code in human auditory cortex. eLife.
https://doi.org/10.7554/eLife.53051
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Joseph G. Makin, David A. Moses, & Edward F. Chang (2020). Machine translation of cortical activity to text with an encoder–decoder framework. Nature Neuroscience.
https://doi.org/10.1038/s41593-020-0608-8
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Yulia Oganian & Edward F. Chang (2019). A speech envelope landmark for syllable encoding in human superior temporal gyrus. Science Advances.
https://doi.org/10.1126/sciadv.aay6279
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David A. Moses, Matthew K. Leonard, Joseph G. Makin, & Edward F. Chang (2019). Real-time decoding of question-and-answer speech dialogue using human cortical activity. Nature Communications.
https://doi.org/10.1038/s41467-019-10994-4
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Han G. Yi*, Matthew K. Leonard*, & Edward F. Chang (2019). The Encoding of Speech Sounds in the Superior Temporal Gyrus. Neuron. (*Equally contributing authors.)
https://doi.org/10.1016/j.neuron.2019.04.023
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Matthias J. Sjerps, Neal P. Fox, Keith Johnson, & Edward F. Chang (2019). Speaker-normalized sound representations in the human auditory cortex. Nature Communications.
https://doi.org/10.1038/s41467-019-10365-z
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Gopala K. Anumanchipalli*, Josh Chartier*, & Edward F. Chang (2019). Speech Synthesis from Neural Decoding of Spoken Sentences. Nature.
https://doi.org/10.1093/neuros/nyy592
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Sellers, K.K.*, Schuerman, W.L.*, Dawes, H.E., Chang, E.F., & Leonard, M.K. (2019). Comparison of common artifact rejection methods applied to direct cortical and peripheral stimulation in human ECoG. In 2019 9th International IEEE/EMBS Conference on Neural Engineering (NER) (pp. 77-80). IEEE.
https://doi.org/10.1109/NER.2019.8716980
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Breshears, D. Jonathan, Southwell, G., Derek, Chang, E.F. (2018). Inhibition of Manual Movements at Speech Arrest Sites in the Posterior Inferior Frontal Lobe. Neurosurgery.
https://doi.org/10.1093/neuros/nyy592
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Dichter, B.K., Breshears, J.D., Leonard, M.K., & Chang, E.F. (2018). The Control of Vocal Pitch in Human Laryngeal Motor Cortex. Cell. 174, 21-31.
https://doi.org/10.1016/j.cell.2018.05.016
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Chartier, J.*, Anumanchipalli, G.K.*, Johnson, K., & Chang, E.F. (2018). Encoding of articulatory kinematic trajectories in human speech sensorimotor cortex. Neuron. (*Equally contributing authors.)
https://doi.org/10.1016/j.neuron.2018.04.031
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Hamilton, L.S.*, Edwards, E.*, & Chang, E.F. (2018). A spatial map of onset and sustained responses to speech in the human superior temporal gyrus. Current Biology. (*Equally contributing authors.)
https://doi.org/10.1016/j.cub.2018.04.033
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Leonard, M.K., Desai, M., Hungate, D., Cai, R., Singhal, N.S., Knowlton, R.C., & Chang, E.F. (2018). Direct cortical stimulation of inferior frontal cortex disrupts both speech and music production in highly trained musicians. Cognitive Neuropsychology.
https://doi.org/10.1080/02643294.2018.1472559
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Moses, D.A., Leonard, M.K., & Chang, E.F. (2018). Real-time classification of auditory sentences using evoked cortical activity in humans. Journal of Neural Engineering.
https://doi.org/10.1088/1741-2552/aaab6f
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Muller, L., Rolston, J.D., Fox, N.P., Knowlton, R., Rao, V.R., & Chang, E.F. (2018). Direct electrical stimulation of human cortex evokes high gamma activity that predicts conscious somatosensory perception. Journal of Neural Engineering.
https://doi.org/10.1088/1741-2552/aa9bf9
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Conant, D.F., Bouchard, K.E., Leonard, M.K., & Chang, E.F. (2018). Human sensorimotor cortex control of directly-measured vocal tract movements during vowel production. Journal of Neuroscience.
https://doi.org/10.1523/JNEUROSCI.2382-17.2018
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Khoshkhoo S.*, Leonard, M.K.*, Mesgarani, N., & Chang, E.F. (2018). Neural correlates of sine-wave speech intelligibility in human frontal and temporal cortex. Brain and Language. (*Equally contributing authors.)
https://doi.org/10.1016/j.bandl.2018.01.007
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Chang, E.F., Kurteff, G., & Wilson, S.M. (2018). Selective Interference with Syntactic Encoding during Sentence Production by Direct Electrocortical Stimulation of the Inferior Frontal gyrus. Journal of Cognitive Neuroscience.
https://doi.org/10.1162/jocn_a_01215
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Hamilton, L.S., Chang, D.L., Lee, M.B., Chang, E.F. (2017) Semi-automated Anatomical Labeling and Inter-subject Warping of High-Density Intracranial Recording Electrodes in Electrocorticography. Frontiers in Neuroinformatics.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5671481/
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Martin, S., Mikutta, C., Leonard, M.K., Hungate, D., Koelsch, S., Shamma, S., Chang, E.F., del R. Millán, J., Knight, R.T., & Palsey, B.N. (2017). Neural Encoding of Auditory Features during Music Perception and Imagery. Cerebral Cortex.
https://doi.org/10.1093/cercor/bhx271
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Rolston, J.D. & Chang, E.F. (2017). Critical Language Areas Show Increased Functional Connectivity in Human Cortex. Cerebral Cortex.
https://doi.org/10.1093/cercor/bhx271
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Tang, C., Hamilton, L.S., & Chang, E.F. (2017). Intonational speech prosody encoding in the human auditory cortex. Science, 357(6353): 797-801. doi:10.1126/science.aam8577.
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Chiong, W., Leonard, M.K., & Chang, E.F. (2017). Neurosurgical Patients as Human Research Subjects: Ethical Considerations in Intracranial Electrophysiology Research. Neurosurgery, 10.1093/neuros/nyx361.
http://dx.doi.org/10.1093/neuros/nyx361
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Rao, V.R.*, Leonard, M.K.*, Kleen, J.K., Lucas, B.A., Mirro, E.A., & Chang, E.F. (2017). Chronic ambulatory electrocorticography from human speech cortex. NeuroImage, http://dx.doi.org/10.1016/j.neuroimage.2017.04.008. (*Equally contributing authors.)
Leonard, M.K., Baud, M.O., Sjerps, M.J., & Chang, E.F. (2016). Perceptual restoration of masked speech in human cortex. Nature Communications, 13619. doi:10.1038/ncomms13619.
http://dx.doi.org/10.1038/ncomms13619
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Moses, D. A., Mesgarani, N., Leonard, M. K., & Chang, E. F. (2016). Neural speech recognition: continuous phoneme decoding using spatiotemporal representations of human cortical activity. Journal of Neural Engineering, 13(5), 56004.
http://doi.org/10.1088/1741-2560/13/5/056004
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Muller, L., Felix, S., Shah, K.G., Lee, K., Pannu, S., & Chang, E.F. (2016). Thin-film, high density micro-electrocorticographic decoding of a human cortical gyrus. Engineering in Medicine and Biology Society (EMBC), 2016 IEEE 38th Annual International Conference of the. 1528-1531.
http://dx.doi.org/10.1109/EMBC.2016.7591001
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Muller, L. Hamilton, L.S., Edwards, E., Bouchard, K.E., & Chang, E.F. (2016). Spatial resolution dependence on spectral frequency in human speech cortex electrocorticography. Journal of Neural Engineering, 13(5), 056013.
https://dx.doi.org/10.1088/1741-2560/13/5/056013
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Leonard, M.K.*, Cai, R.*, Babiak, M.C.*, Ren, A.*, & Chang, E.F.* (2016). The peri-Sylvian cortical network underlying single word repetition revealed by electrocortical stimulation and direct neural recordings. Brain & Language, doi:10.1016/j.bandl.2016.06.001.
https://dx.doi.org/10.1016/j.bandl.2016.06.001
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Cheung, C., Hamilton, L.S., Johnson, K., & Chang, E.F. (2016). The auditory representation of speech sounds in human motor cortex. Elife, 5:e12577.
https://dx.doi.org/10.7554/eLife.12577
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Hullett, P.W., Hamilton, L.S., Mesgarani, N., Schreiner, C.E., & Chang, E.F. (2016). Human superior temporal gyrus organization of spectrotemporal modulation tuning derived from speech stimuli. Journal of Neuroscience, 36(6): 2014-2026.
Breshears, J.D., Molinaro, A.M., & Chang, E.F. (2015). A probabilistic map of the human ventral sensorimotor cortex using electrical stimulation. Journal of Neurosurgery, 123: 340-349.
https://dx.doi.org/10.3171/2014.11.JNS14889
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Cibelli, E.S., Leonard, M.K., Johnson, K., & Chang, E.F. (2015). The influence of lexical statistics on temporal lobe cortical dynamics during spoken word listening. Brain and Language, 147: 66-75.
https://dx.doi.org/10.1016/j.bandl.2015.05.005
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Houde, J.F. & Chang, E.F. (2015). The Cortical computations underlying feedback control in vocal production. Current Opinion in Neurobiology, 33: 174-181.
https://dx.doi.org/10.1016/j.conb.2015.04.006
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Leonard, M.K., Bouchard, K.E., Tang, C., & Chang, E.F. (2015). Dynamic encoding of speech sequence probability in human temporal cortex. Journal of Neuroscience, 35(18): 7203-7214.
https://dx.doi.org/10.1523/JNEUROSCI.4100-14.2015
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Chang, E.F. (2015). Towards large-Scale, human-Based, mesoscopic neurotechnologies. Neuron, 86: 68-78.
Bouchard, K.E. & Chang, E.F. (2014). Control of spoken vowel acoustics and the influence of phonetic context in human speech sensorimotor cortex. Journal of Neuroscience, 34(38): 12662-12677.
https://dx.doi.org/10.1523/JNEUROSCI.1219-14.2014
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Leonard, M.K. & Chang, E.F. (2014). Dynamic speech representations in the human temporal lobe. Trends in Cognitive Science, 18(9) 472-479.
https://dx.doi.org/10.1016/j.tics.2014.05.001
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Mesgarani, N., Cheung, C., Johnson, K., & Chang, E.F. (2014). Phonetic feature encoding in human superior temporal gyrus. Science, 343(6174): 1006-1010.
https://dx.doi.org/10.1126/science.1245994
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See Perspective from Grodzinsky, Y. & Nelken, I. (2014). The neural code that makes us human. Science, 343(6174):978-9. https://dx.doi.org/10.1126/science.1251495.
Conant, D., Bouchard, K.E., & Chang, E.F. (2014). Speech map in the human ventral sensory-motor cortex. Current Opinion in Neurobiology, 24C: 63-67.
Edwards, E. & Chang, E.F. (2013). Syllabic (2-5Hz) and fluctuation (1-10Hz) ranges in speech and auditory processing. Hearing Research, 305: 113-34.
https://dx.doi.org/10.1016/j.heares.2013.08.017
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Houde, J.H., Kort, N.S., Niziolek, C.A., Chang, E.F., & Nagarajan, S.S. (2013). Neural evidence for state feedback control of speaking. Proceedings of Meetings on Acoustics, 19: 060178.
http://dx.doi.org/10.1121/1.4799495
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Bouchard, K.E., Mesgarani, N., Johnson, K., & Chang, E.F. (2013). Functional organization of human sensorimotor cortex for speech articulation. Nature, 495(7441):327-332.
https://dx.doi.org/10.1038/nature11911
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Chang, E.F.*, Niziolek, C.*, Nagarajan, S.S., Knight, R.T., & Houde, J.S. (2013). Human cortical sensorimotor network underlying feedback control of vocal pitch. Proceedings of the National Academies of Sciences, 110(7): 2653-2658.
Cheung, C. & Chang, E.F. (2012). Real-time, single-trial mapping of cortical event-related activation. Journal of Neural Engineering, 9(4):046018.
Mesgarani, N. & Chang, E.F. (2012). Selective cortical representation of attended speech in multi-talker speech perception. Nature, 485(7397):233-236.
https://dx.doi.org/10.1038/nature11020
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Pasley, B., David, S.V., Mesgarani, N., Flinker, A., Shamma, S.A., Crone, N.E., Knight, R.T., & Chang, E.F. (2012). Reconstructing speech from human auditory cortex. PLoS Biology, 10(1): e1001251.
Chang, E.F.*, Rieger, J.*, Johnson, K.D., Berger, M.S., Barbaro, N.M., & Knight, R.T. (2010). Categorical speech representation in the human superior temporal gyrus. Nature Neuroscience, 13(11): 1428-32.
https://dx.doi.org/10.1038/nn.2641
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Chang, E.F.*, Edwards, E.*, Nagarajan, S.S., Fogelson, N., Dalal, S.S., Canolty, R.T., Kirsch, H.E., Barbaro, N.M., & Knight, R.T. (2010). Cortical spatiotemporal dynamics underlying phonological target detection in humans. Journal of Cognitive Neuroscience, 23(6): 1437-1446.
De Villers-sidani, E., Chang, E.F., Bao, S., & Merzenich, M.M. (2007). Critical period window for spectral tuning defined in the primary auditory cortex (A1). Journal of Neuroscience, 27(1): 180-189.
Chang, E.F., Bao, S., Imaizumi, K., Schreiner, C.E., & Merzenich, M.M. (2005). The development of spectral and temporal response selectivity in the auditory cortex. Proceedings of the National Academy of Science. 102(45):16460-16465.
Bao, S., Chang, E.F., Woods, J., & Merzenich, M.M. (2004). Temporal plasticity in the primary auditory cortex induced by operant perceptual learning. Nature Neuroscience, 7(9):974-981.
Chang, E.F. & Merzenich, M.M. (2003). Environmental noise retards auditory cortical development. Science, 300(5618): 498-502.